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Science & physiology
VO2 max is a summary of how well the whole system works
VO2 max gets a lot of attention right now, and it's earned, since it's one of the strongest predictors of how long people live. What I think gets lost is what it's actually measuring, which is how well the body takes in oxygen, moves it and uses it. Every cell depends on that, so the number is really a summary of how efficiently the whole system is working.
The way to improve it is to push the heart and lungs past what's comfortable for a while and then let them recover. That's hormesis, a dose of stress that leaves the system stronger, and the biggest gains usually show up in people starting near the bottom.
Oxygen matters outside the gym too. At night, sleep apnea can drop oxygen levels over and over without someone knowing it's happening. During the day, a lot of people at a desk breathe shallow and high in the chest, or hold their breath while they work through email, and that pattern tends to keep the body in a more stressed state. I don't think the fix is complicated, but it starts with noticing it.